The Present Paradigm Shift in Genetics.

Post questions or suggestions here.
Locked
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

For the last decade or so biologists believed that they possessed a fairly complete comprehension of cell biology, but now with improving technology they are beginning to see just how small and fragmented their views were. Since the discovery of the double helix DNA in the 1960s, scientists assumed that the DNA molecule was the Holy Grail of understanding disease and dysfunction at the cellular level. However, as they begun to map the human genome in contrast to other organisms, many more questions were raised than answers, as their discoveries didn’t quite fit with their initial assumptions.

The most bewildering observation is how simple organisms seemed to have the same number of productive genes as more complex ones. For instance: Humans and Flies both have the same number of protein encoding genes (roughly 20, 000), so scientists were baffled in terms of trying to explain the differences in complexity between the two. They thought, “Surely, if the genome is the center of the cell then a more complex organism should have far more genes than a less complex one”

But the molecule they overlooked was the RNA molecule, as it is much more significant than first assumed. In the beginning scientists observed that the function of RNA seemed to be very humble and feminine compared to DNA, as they observed its main duty was to carry and fetch atomic materials for the DNA to forge proteins. So if DNA were the Blacksmith of the town, RNA would be his humble assistant wife. And so DNA was viewed as significantly more masculine than RNA, and this is probably why scientists ignored it for so long.

However, as they continued mapping the human genome, new types of RNA started popping up all over the place, types that couldn’t be accounted for, and they were found in places throughout the cell that they shouldn’t have been. So more energy was put into understanding them, and scientists are now discovering that the relationship between DNA and RNA is far more complex than ever imagined. The initial assumption was that the primary function of the genes was designated solely for protein production, and scientists simply labeled the rest junk DNA. But as they continued studying cross-sections of the ‘junk DNA’, they discovered that the genes were in fact encoding alien shaped RNA molecules that they never seen before.

So this raised the question – what the hell is all this RNA doing here? And how many different types of RNA are there? Essentially, after much research, what is now believed is that the RNA represents most of the operating system for the cell. For instance: If DNA was the CEO of the cell, RNA would represent hundreds or even thousands of managers, supervisors, administrators, secretaries, HR people,and so on.

So the complexity of organisms is governed by how many different specializations of RNA there are, and how complex their relationships are. So as organisms evolved, RNA became much more specialized from its humble beginnings. For instance: Instead of just carrying atomic materials for DNA, new types of RNA evolved to regulate the input and output of information to and from the cell to other cells throughout the body, much like a secretary/administer for a company. And from there, more specializations evolved.

So RNA, as a feminine force probably has very complicated networks with other RNA allies throughout the body. So the more specialized, plentiful, and complex the types of RNA become, the better equipped the organism is at regulating its interconnected organs and tissues. Moreover, currently scientists believe that there are about 20, 000 protein encoding genes in humans which was thought to be the majority of the useful DNA. But Now, scientists believe that there could be up to 150, 000 additional RNA encoding genes, which actually make up the majority of the genome. Most of which, they still don’t understand.

So the genome is designed primarily for RNA production, rather than protein production, as first believed. Scientists have also discovered a type of RNA that could ultimately change the consensus on evolutionary theory. Based on the findings, both natural selection and Lamarckism could be partly true because a newly discovered RNA molecule is thought to modify the DNA skeleton based on environmental stimulus as a means to better adapt it. So the importance of RNA’s function in the cell is changing the entire manner in which the medical profession and the academics alike think about genetics. In my opinion, the medical profession will have more luck treating RNA defects in many diseases because the RNA is both the servant and the master to DNA. So because RNA seems to have many more responsibilities, understanding what can go wrong with RNA will probably prove to be very detrimental in treating disease and mental/hormonal disorder.
User avatar
Cory Duchesne
Posts: 2320
Joined: Thu Feb 02, 2006 10:35 am
Location: Canada
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by Cory Duchesne »

Thanks for the update.
So if DNA were the Blacksmith of the town, RNA would be his humble assistant wife.
Isn't the RNA quite a bit more multitudinous than the DNA? If that's the case, let's consider the RNA as the miners slaving away for the ore, and the DNA is like the blacksmith.
So because RNA seems to have many more responsibilities, understanding what can go wrong with RNA will probably prove to be very detrimental in treating disease and mental/hormonal disorder.
I think you mean beneficial.
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

Re: The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

Cory,
Isn't the RNA quite a bit more multitudinous than the DNA? If that's the case, let's consider the RNA as the miners slaving away for the ore, and the DNA is like the blacksmith.
This is my inference based on what science claims, and using life as a metaphor, so I'm not absolutely certain.

Well, based on what science now knows, proteins (enzymes) are used to break down food in the stomach and then it is transported to the appropriate area of the body through the bloodstream after it is absorbed in the intestines, and as far as we know RNA doesn’t leave the cells so it can’t be the miners in that sense. So proteins do the bull work (and they are created by DNA, with the help of RNA), So DNA creates both the Masculine and Feminine forces in the body, as RNA is more like a carrier, administrator, manager, communicator, organizer that stays inside the cell, and she picks up the broken down molecules at the cell wall, and carries them to the desired locations for use. Basically, She knows where everything is, and she knows what everyone needs, while the DNA single-mindedly forges the needed proteins and RNA, according to the information provided by the existing RNA.
User avatar
daybrown
Posts: 708
Joined: Sun Sep 16, 2007 4:00 pm
Location: SE Ozarks
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by daybrown »

And if it isnt complex enuf already factor in methyl tags; which from what I can tell hang like ticks from certain points on the DNA which empower or disable it. The most convincing evidence I know of was a Swedish study showing how a generation that suffered malnutrition growing up had grandchildren with certain characteristics.

But no discernable diff with children. It looks like every generation receives the reciprocal pattern of methyl tags, so that the 3rd generation then resembles the 1st, which is something that has long been noted in family lines. Throwbacks.

But perhaps more to the point, is that behaviorism is not sufficient to produce the kind of next generation we all hope for. Genetic endowment, or challenge, is ever more obvious, and more obvious with some races than others. While we dont understand the software of DNA, RNA, and methyl tags, we do see some markers that show up in very signficicant statistical numbers in the demographics.

So long as the professional class is globally mobile, the culture which figures this out, and offers the best education to their progeny while wasting as little as possible on those who are not educable, and thereby offers the lowest taxes, will draw the greater numbers of talented creative people. The culture which figures out how to curtail the breeding of the welfare classes will be seen as more forward looking, and we all know will have the lower rate of socio pathology hindering sustainable development.

Everybody despises what the Nazis did in sterilizing and murdering the less socially useful, and ignores the fact that a generation later Germany enjoys a lower rate of genetic diseases. i do not, however, doubt that there are some in the power elites who have noticed this, and are taking steps to promote economic development in those regions with lower rates of sociopathology. And withdrawing investment from those which have higher rates.

Equal opportunity sounds nice, but it is appropriate opportunity, that maximizes talent where it is that draws the most investment to improve the schools, encourage entrepreneurialism, and maintain or improve the environment with a more watchful eye on sustainable development- that draw more of the highly talented where more genetically endowed highly talented kids will be born and raised.

It would be refreshing to see the political and economic leadership admit what it already is doing in this, perhaps take the heat for being racist, but nevertheless demonstrate how it draws even more talented people in to join the effort. Not that I am adverse to studying why some progeny are more promising, and what steps mite be taken to maximize the development of children no matter what the race.

But if that effort is to be made, it'll be done by the very, somewhat racist, communities whose productivity is so high that they can afford to fund it.
Goddess made sex for company.
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

Re: The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

Daybrown,
And if it isnt complex enuf already factor in methyl tags; which from what I can tell hang like ticks from certain points on the DNA which empower or disable it.
My guess is that the methyl tags are activated or deactivated by different types of RNA, which cause the DNA to forge different materials such as proteins or new RNA molecules.

Moreover, I bet that networks of RNA keep track of what needs to be produced, and where it needs to be sent, and then a command is sent for another type of RNA to hook up to a methyl tag on the appropriate chromosome, thus causing the DNA to perform the desired action.

And I also suspect that some types of higher tier RNA are probably more masculinized, especially if we are talking about thousands of different types. For instance: Scientists now know of a type of RNA that’s function is to shut off some of the duplicate X chromosomes in the female ovum as a means to prevent duplicate X material from being activated during fetal development.
User avatar
daybrown
Posts: 708
Joined: Sun Sep 16, 2007 4:00 pm
Location: SE Ozarks
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by daybrown »

However RNA, DNA, and methyl tags work, the cumulative result, as seen in Bouchard's studies of identical twins raised by different families proves there is a very powerful genetic effect.

Alan Greenspan:"It wont matter how much money we throw at medicare if there are not enuf nurses to deliver it." And there's a shortage already, even before the boomers retire. And while Head Start and all these other educational opportunities may be necessary, they are not sufficient. If the girl does not have a talented momma, you are never going to make a talented nurse out of her.

And when you look at the nurses, its the same as the military families, the musicians, bankers, or- street thugs and drug addicts. Some of the DNA markers for alcoholism have been identified.

So- we either advise young women now of what kind of progeny their DNA will produce, or what they can expect from more promising sperm donation and in Vitro, and get them to dramatically ramp up the production of the kind of women needed to support the social safety net, or- get your ass out of the way cause you do not want to be there when it tears apart.

I know it sounds like Nazism, but that is the way it is.
Goddess made sex for company.
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

Re: The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

Daybrown,
So- we either advise young women now of what kind of progeny their DNA will produce, or what they can expect from more promising sperm donation and in Vitro, and get them to dramatically ramp up the production of the kind of women needed to support the social safety net, or- get your ass out of the way cause you do not want to be there when it tears apart.
Eventually, I suspect genetic engineering will allow us to masculinize both female and male fetuses to the highest possible degree, which will help to maximize intelligence. And let us not forget that the introduction of IT technology over the last century has increased the overall general intelligence of the population, which should continue. Not to mention that the more technological a society becomes, the easier it is for the emotionally unstable to self-destruct, which hopefully happens before they give a chance to reproduce.

And lets not wish away all the stupid people too prematurely, as they're still needed for many of the undesirable jobs that intellectuals refuse to do.
User avatar
daybrown
Posts: 708
Joined: Sun Sep 16, 2007 4:00 pm
Location: SE Ozarks
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by daybrown »

I appreciate the consideration Ryan, but the genetic engineering side of the human genome is several orders of magnitude more complex than doing it for corn, and fraught with unseen unintended consequences.

Doing it the old fashioned way, breeding hominids the same as you'd do with any other livestock, wont guarantee that every conception will have the desired characteristics, but the whole generation will turn out to be more like we hope for.

As for stupid people, we already have robots that are easier to program and dont show up for work hungover on monday morning. The rest of what we need to do we should be doing ourselves. Any smart person who has looked into maximizing their mental functioning comes to realize that physical activity is necessary.

Simply trading the time now spent in the gym for real physical labor to get something useful done will eliminate the need for 95% of the dull witted. I'd not want to eliminate them from the gene pools entirely, for there may be other unrealized benefits in the DNA code.
Goddess made sex for company.
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

Re: The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

Daybrown,
I appreciate the consideration Ryan, but the genetic engineering side of the human genome is several orders of magnitude more complex than doing it for corn, and fraught with unseen unintended consequences.
Yes, but in 200-300 years, our understanding of genetics, and the state of technology will be so advanced that tinkering with the genome could become as standard as replacing your motherboard, think ahead…
Any smart person who has looked into maximizing their mental functioning comes to realize that physical activity is necessary.
As of late, I hardly ever exercise besides just walking around, so do you think a good workout increases your mental capacity? What empirical evidence do you have? Actually, there are many jogging addicts that scoot by my window regularly, but they don’t seem to be all that smart… : )
Simply trading the time now spent in the gym for real physical labor to get something useful done will eliminate the need for 95% of the dull witted.
I used to think that the gym was a waste of time as well, but with the gym. At least the resistance of the weights is regulated, and therefore less dangerous than being a ruff neck for some immoral construction company. I’ve worked construction, and I’ve attended the gym, and I’d rather choose the gym over hard labor any day. It’s safer, and much more sane as far as expectations is concerned.

Men have a lower life expectancy over women for this reason. They do hard labor jobs that destroy their bodies because the pace and expectations are too extreme, and this is why if the labor doesn’t do them in, their substance abuse usually does instead. It is a vicious cycle, laborers will come home with sore muscles, totally exhausted, and use some sort of pleasurable vice to smoother the pain and discomfort.
User avatar
daybrown
Posts: 708
Joined: Sun Sep 16, 2007 4:00 pm
Location: SE Ozarks
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by daybrown »

There are studies to surf for suggesting that longer playground activity would cope with ADD better than Ritalin. Some kids just need to be more physically active. And we know the activity increases the blood flow, so natuarlly, that would include the flow feeding the gray matter.

Half the Green Berets grew up on family farms. That's 1% of the total population providing 50% of the nation's most competent soldiers. I live in an area of family farms, and when you surf the school report, the numbers just jump out at you. ZERO rates of violence. dropout rates in the single digits, graduation rates near 90%, and attendance rates at 95%. Classes that average from the 55th tyo 65th percentile.

Farm kids usta be thot stupid. Gov. Clinton went after that, providing broadband to every school in Arkansas. But when a farm kid gets home, he has a pitchfork in his hand, not a digital remote.

The urban autism rate: 1:155. The data from small schools is hard to evaluate, but from a school nurse and others I spoke with, the farm kid rate is 1:4000. The posted austism rate for the Amish:1:15,000. Those kids get even more work and no junkfood at all.

Part of the problem with genetics is that different hominid lines evolved in different areas that had different mineral profiles. And when those minerals are missing in the diet there are physical problems like goiter, but also mental development problems. Neurology studies with rats show how necessary trace minerals are to empower neurotransmitters to lay down new neural pathways during learning.

Hominids evolved in small isolated tribal groups; which is why we have incest taboos, whereas mass herd animals dont worry about it. Cows commonly mate with the sire, and it is even deliberately done trying to improve a line. These techniqes are pretty well worked out, and already we see the markers for hominid genetic problems like sickle cell or hemophilia that just avoiding incest does not deal with.

The most successful economy in the global market over the next century or so will be that which identifies these genetic risk factors, and convinces women to choose from better, more adaptive, Y chromosome lines. Sparta had remarkable success based on what they knew the competition to be, in just 5 generations.

But its not upta us. I hear young women are already looking into fertility clinics and raising kids so sired in Lesbian communes. This freaks a lotta guys out, but the genetic endowment is so much more powerful than the feminist socialization that the boys I've seen turn out as functional, or moreso, than others.

One clue I know from History about that was Machiavelli saying that you should always let the son inherit the estate after you have the father killed. Half the sons will have hated the old man so much they will be secret allies.
Goddess made sex for company.
User avatar
Ryan Rudolph
Posts: 2490
Joined: Sun Jan 29, 2006 10:32 am
Location: British Columbia, Canada

Re: The Present Paradigm Shift in Genetics.

Post by Ryan Rudolph »

Daybrown,
There are studies to surf for suggesting that longer playground activity would cope with ADD better than Ritalin. Some kids just need to be more physically active. And we know the activity increases the blood flow, so natuarlly, that would include the flow feeding the gray matter.
Interesting. Yes, and there must be some other benefits, which prevents neurological deterioration as well, besides just increased blood flow.
The most successful economy in the global market over the next century or so will be that which identifies these genetic risk factors, and convinces women to choose from better, more adaptive, Y chromosome lines. Sparta had remarkable success based on what they knew the competition to be, in just 5 generations.
What do you think the ideal Y chromosome specimen is Daybrown? What are some of the necessary characteristics in your opinion?
User avatar
daybrown
Posts: 708
Joined: Sun Sep 16, 2007 4:00 pm
Location: SE Ozarks
Contact:

Re: The Present Paradigm Shift in Genetics.

Post by daybrown »

There is no ideal; Women have DNA markers too, and the best match will require different DNA markers from both XX and XY. There are men of character and talent in every gene pool; but finding a line that consistently has good results requires good genealogy data. Which is mostly limited to Native Europeans and East Asians.

And for sure, the women will be bringing their own lists of preferences to fertility clinics. We already see what smart white women who make enuf money to afford nannies (rather than husbands) choose. Fair haired Nordic men.

Everyone knows about the Viking warriors; but what they dont think about is that while the alpha males who enjoyed dominating women chose to stay in conquered lands, only the beta males who didnt mind female leadership went back to Scandinavia. And the only ones who returned were those with the most robust immune systems after being exposed to a host of diseases in foreign lands. Some even have resistance to HIV.

While the skin cancer rate is higher, with modern medical diagnosis, that's no problem. And for women with higher melanin levels, the mtDNA would supply protection.

From the reports I saw on CNN and CBS' 60 Minutes, the women also look for biographical clues to altruism; not money, but time donated to environmentalism or social causes. They, quite rightly, believe that such progeny, when grown, will be more attentive to a mother's needs. Contrairily, they dont want stud muffins, whose only talent is pleasing other young women. Other women are producing their progeny in sufficient numbers that smart women who want any wont have any problem finding them at maturity.

They prefer sperm donations from med school students, so they know academic performance is good, but dont, AFAIK, select from Law schools- whose students are more likely to be social predators. 60 minutes showed a network of women who'd all born the progeny of a particular med school student, somewhere about 20 progeny, all of whom appear to be everything their mothers would hope for.

Some were now only toddlers while others were just entering college. Without any voice over, I noted that all of them were towheads. The sperm donor is now a successful doctor, but the women respect his privacy. I expect we will see more of these networks, where women will not only look at the DNA data and biography, but track down the women who've already had kids from a line to see how they turned out.

Whether we like it or not, this is a eugenics program. I dont see any way to stop it. I have suggested that it'd be only fair to offer fertility clinics to all young women who are not satisfied with the local stud muffin pool. Sperm donation was reported costing a few hundred. Tax payers who funded this would find dramatic declines in problems from the welfare classes as the kids enter school, puberty, and the workforce.

But its not upta us. The smart successful white women, most of whom see that the men of their station in their careers are already married to sexy airheads know they cant compete with that, and are not bothering to try. I read a magazine article on new forms of women's literature, which include novels showing what a thankless task it is for them to marry a divorced man and then try to raise his kids born by an airhead.

When you iterate the progression of this policy by successful white women you can see a Platonic republic arising out of it, with their talented kids rising to the top of the transnational management. This whole thing challenges both liberal and conservative sensibilities. The Nazis and white supremacists wont like it either since none of them will make the cut at the fertility clinics. The irony is only slightly less rich than the kids will be as they grow up.
Goddess made sex for company.
Locked